Latest Updates in coumarin scaffolds as potent antiproliferative agents (2018-2023)

Document Type : Review articles

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1 Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

2 Medicinal Chemistry Department, Faculty of Pharmacy, Minia University

Abstract

The coumarin scaffold is an essential class of organic heterocyclic derivatives. Coumarin derivatives have different biological activities such as anticoagulant, anti-hypertensive, antibacterial, antiviral, anticancer, antifungal, anti-inflammatory, and others. Furthermore, many marketed drugs contain coumarin core. Moreover, Coumarin derivatives have remarkable antiproliferative activity and exert their effects through different mechanisms of action, such as induction of apoptosis and cell cycle arrest at various stages and inhibition of EGFR and aromatase inhibition. Many antiproliferative agents encompass coumarin cores that have achieved great attention in the literature. Here, we mention the coumarin scaffold trials as antiproliferative agents in the literature from 2018 to 2023. Furthermore, we examined the significant prospects in cancer treatment using coumarin derivatives that could orient medicinal chemists for a forceful future strategy of more effective antiproliferative agents. The distinctiveness of this mini review is in the emphasized coumarin scaffold hybridization with other active pharmacophores, detailed mechanisms of action beyond their antiproliferative activities, and their structure-activity relationship.

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