ANALYSIS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANTAGONISTS

Document Type : Review articles

Authors

1 Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

2 Analytical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt.

3 Analytical chemistry, Faculty of Pharmacy, Assiut, Egypt.

4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut , Egypt

Abstract

The Angiotensin-converting enzyme inhibitors and antagonists are widely used in the management of essential hypertension, stable chronic heart failure, myocardial infarction and diabetic nephropathy,so that specific and sensitive methods are needed for the qualitative and quantitative determinations of these drugs in pharmaceutical dosage forms and in biological material. In the last few years, there was no review published covering all different analytical methods used for the determination of these drugs. The aim of this work is to review the most important recent methods for their analysis in pure forms, in different pharmaceutical dosage forms and in biological fluids due to the great importance of this class of drugs. This review includes two parts: the first part presents the methods applied for the analysis of pharmaceuticals. The second part is devoted to the methods elaborated for the assays in biological material (blood, plasma and urine).

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